IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
S. Rai, Y. Zhang, E. Grockowiak, Q. Kimmerlin, N. Hansen, C. B. Stoll, M. Usart, H. Hao-Shen, M. S. Bader, J. Passweg, S. Dirnhofer, C. J. Farady, T. Schroeder, S. Mendez-Ferrer, R. C. Skoda
This study shows IL-1β promotes MPN initiation by enhancing early clonal expansion of JAK2-mutant HSCs in a mouse model.
bioRxiv · May 21, 2023 · PreprintCancer Biology