Author

C. J. Farady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Unterreiner· 2 shared A. Boettcher· 1 shared A. Kostina· 1 shared B. Roediger· 1 shared B. S. Saller· 1 shared C. Agarinis· 1 shared C. B. Stoll· 1 shared C. J. Gross· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

A. Unterreiner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent

L. Wang, A. Unterreiner, R. Kapetanovic, S. Aslani, Y. Xiong, K. A. Donovand, C. J. Farady, E. S. Fischer, F. Bornancinc, P. Matthias

The study shows that HDAC6's role in inflammasome formation varies depending on the cellular context and model system used.

bioRxiv · Aug 15, 2023Immunology

IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

S. Rai, Y. Zhang, E. Grockowiak, Q. Kimmerlin, N. Hansen, C. B. Stoll, M. Usart, H. Hao-Shen, M. S. Bader, J. Passweg, S. Dirnhofer, C. J. Farady, T. Schroeder, S. Mendez-Ferrer, R. C. Skoda

This study shows IL-1β promotes MPN initiation by enhancing early clonal expansion of JAK2-mutant HSCs in a mouse model.

bioRxiv · May 21, 2023 · PreprintCancer Biology

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

D. Heiser, J. Rubert, A. Unterreiner, C. Maurer, M. Kamke, U. Bodendorf, C. J. Farady, B. Roediger, F. Bornancin

This study evaluates PKD auto-phosphorylation as a biomarker for NLRP3 inflammasome activation, finding it precedes inflammasome activity but is also triggered by non-NLRP3 stimuli.

bioRxiv · Mar 4, 2021Cell Biology