Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells
S. Sivakumar, E. Abu-Shah, D. Ahern, E. H. Arbe-Barnes, N. Mangal, S. Reddy, A. Rendek, A. Easton, E. Kurz, M. Silva, L. R. Heij, Z. Soonawalla, R. Bashford-Rogers, M. R. Middleton, M. Dustin
This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.
bioRxiv · Jun 20, 2020 · PreprintImmunology