L. R. Heij

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

KIF23 regulation by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

This study identifies miR-122's role in liver disease by showing its antagonistic effects on NRF1 and E2F4 and its impact on proteins linked to malignancy.

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

The paper analyzes nerve fiber density and tertiary lymphoid structures in pancreatic cancer, finding that high nerve fiber density and TLS count correlate with improved survival.

Enhanced inflammatory response mediated by parenchymal cells associates with resistance towards mTOR inhibition

This study shows that mTOR inhibition in liver epithelial cells enhances inflammation and accelerates liver metastases, suggesting non-malignant cells contribute to resistance against mTOR inhibitors.

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.