Author

A. Easton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Animal Behavior & Cognition· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

G. N. Valbuena· 2 shared S. J. Leedham· 2 shared T. Maughan· 2 shared A. A. Ahmed· 1 shared A. C. Koong· 1 shared A. Coosemans· 1 shared A. D. Campbell· 1 shared A. Geremia· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

G. N. Valbuena

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Author profile →

8 papers

Recent·Most cited

Mice remember experiences via conspecific-context: models of social episodic-like memory

T. W. Ross, S. L. Poulter, C. Lever, A. Easton

This study develops new social spontaneous recognition tasks to assess episodic-like memory in mice, showing they use conspecifics as contextual cues to distinguish unique episodes.

bioRxiv · Aug 4, 2023Animal Behavior & Cognition

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

LARP1 regulates metabolism and mTORC1 activity in cancer

J. Chettle, Z. Dedeic, R. Fischer, I. Vendrell, L. Campo, A. Easton, M. Browne, J. Morris, H. Schwenzer, P. Lascaux, R. Gijsbers, E. Pires, D. J. Royston, D. J. P. Ferguson, A. Coosemans, , S. P. Blagden

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology

Multi-environment QTL analysis delineates a major locus associated with homoeologous exchanges for water-use efficiency and seed yield in allopolyploid Brassica napus

H. Raman, R. Raman, R. Pirathiban, B. McVittie, N. Sharma, S. Liu, Y. Qiu, A. Zhu, A. Killian, B. Cullis, G. Farquhar, H. S. Williams, R. White, D. Tabah, A. Easton, Y. Zhang

This study identifies a major QTL on chromosome A09 associated with water-use efficiency and seed yield in Brassica napus, linked to homoeologous exchanges and gene expression differences.

bioRxiv · Jul 8, 2021 · PreprintPlant Biology

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

M. Friedrich, M. Pohin, M. A. Jackson, I. Korsunsky, S. Bullers, K. Rue-Albrecht, Z. Christoforidou, D. Santhananthan, R. Ravindran, R. Sanches Peres, H. Sharpe, K. Wei, G. F. M. Watts, E. H. Mann, A. Geremia, , F. M. Powrie

bioRxiv · Feb 5, 2021 · PreprintImmunology

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

S. Sivakumar, E. Abu-Shah, D. Ahern, E. H. Arbe-Barnes, N. Mangal, S. Reddy, A. Rendek, A. Easton, E. Kurz, M. Silva, L. R. Heij, Z. Soonawalla, R. Bashford-Rogers, M. R. Middleton, M. Dustin

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

bioRxiv · Jun 20, 2020 · PreprintImmunology

Global proteomics of Ubqln2-based murine models of ALS

A. M. Whiteley, M. A. Prado, S. A. H. de Poot, J. A. Paulo, M. Ashton, S. Dominguez, M. Weber, H. Ngu, J. Szpyt, M. P. Jedrychowski, A. Easton, S. P. Gygi, T. Kurz, M. J. Monteiro, E. J. Brown, D. Finley

The paper identifies proteomic changes in Ubqln2 mutant mice and finds that TRIM32, PEG10, and CXX1B are linked to UBQLN2 function and degradation.

bioRxiv · Feb 22, 2020Cell Biology