Glutathione overproduction mediates lymphoma initiating cells survival and has a sex-dependent effect on lymphomagenesis
A. H.-Alcantara, O. Kourani, A. Marcos-Jimenez, P. Martinez-Nunez, E. Herranz-Martin, P. Fuentes, M. L. Toribio, C. Munoz-Calleja, T. Iglesias, M. R. Campanero
This study shows that glutathione overproduction enables lymphoma initiating cells to survive in soft gels and that targeting glutathione production can inhibit lymphoma growth, with a sex-dependent effect observed in mice.
bioRxiv · Nov 22, 2023 · PreprintCancer Biology