E. Huerta-Sanchez

The MUC19 Gene: An Evolutionary History of Recurrent Introgression and Natural Selection

The paper identifies a Denisovan-like MUC19 haplotype in Indigenous Americans and Neanderthals, showing it is under positive selection and has high copy numbers of a tandem repeat.

The Utility of Ancestral and Derived Allele Sharing for Genome-Wide Inferences of Introgression

This study introduces new methods for detecting introgression by incorporating ancestral allele sharing, finding they perform comparably to existing derived allele sharing methods.

Integrating sex-bias into studies of archaic admixture on chromosome X

This paper investigates how sex-bias in archaic hominin populations affects the retention of archaic DNA on chromosome X compared to autosomes using simulation studies.

Leveraging shared ancestral variation to detect local introgression

The paper introduces a new statistic, D+, to detect local introgression by incorporating both shared ancestral and derived alleles, showing improved precision over existing methods.

Pharmacogenetic variation in Neanderthals and Denisovans and implications for human health and response to medications

The paper examines pharmacogenetic variation in Neanderthals and Denisovans and identifies potential functional differences in drug-metabolizing genes between archaic and modern humans.

The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans

The paper investigates the origin and timing of Denisovan introgression into Tibetans at the EPAS1 locus, finding an East Asian-specific introgression event around 43,000 years ago followed by selection 12,000 years ago.

Recessive deleterious variation has a limited impact on signals of adaptive introgression in human populations

This study shows that recessive deleterious variants can increase false positives in detecting adaptive introgression, but most signals remain robust, with HYAL2 and HLA being particularly affected.

Archaic adaptive introgression in TBX15/WARS2

The paper identifies an archaic adaptive introgression in the TBX15/WARS2 region in Greenlandic Inuit, showing its association with gene expression and DNA methylation changes.