T. Hansen

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

This study shows that fecal microbial load, not disease, is the main driver of gut microbiome changes and identifies it as a major confounder in microbiome studies.

Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 ℃

The paper shows ice nucleation proteins self-assemble into fibres that trigger freezing near 0 ℃ by forming multimers essential for frost formation.

Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance

This study shows that mutations in pgsA increase membrane fluidity and cell wall thickness in daptomycin-resistant S. aureus, contributing to resistance.

Metabolomics reveals nucleoside analogs for regulating mucosal-associated invariant T cell responses

The paper identifies nucleoside analogs from Mycobacterium tuberculosis that regulate MAIT cell activation, revealing conserved ligands across bacterial and mammalian systems.

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

High-throughput UHPLC-MS to screen metabolites in feces for gut metabolic health

This study develops a high-throughput UHPLC-MS method to screen fecal metabolites for gut metabolic health, identifying 28 metabolites with quantitative profiles in patients with alcohol-related liver disease and healthy controls.

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

This study identifies the BRCA2-PP2A-B56 complex as essential for efficient DNA repair by homologous recombination and shows that cancer mutations disrupt this interaction, increasing sensitivity to PARP inhibition.

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivity.

This study identifies sol-SorCS1 as a soluble form of SorCS1 that enhances insulin sensitivity by binding the insulin receptor, improving glucose uptake and signaling in myocytes.

A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver disease

This study identifies circulating proteomic biomarkers for alcohol-related liver disease using paired liver biopsy and plasma proteomics, showing improved performance over existing tests.

Pex14p phosphorylation modulates import of citrate synthase 2 into peroxisomes in Saccharomyces cerevisiae

This study shows that phosphorylation of Pex14p at serine 266 regulates the import of Cit2p into peroxisomes, affecting yeast metabolism under different carbon sources.

Archaic adaptive introgression in TBX15/WARS2

The paper identifies an archaic adaptive introgression in the TBX15/WARS2 region in Greenlandic Inuit, showing its association with gene expression and DNA methylation changes.