K. Yuan

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

A novel architecture of PT neuron-based corticothalamic connectivity in the auditory system

The paper reveals a fully-connected corticothalamic architecture in the auditory system, showing L5 neurons project broadly to thalamic modules, challenging traditional hierarchical models.

The Geometric Evolution of Aortic Dissections: Predicting Surgical Success using Fluctuations in Integrated Gaussian Curvature

This paper introduces a geometric descriptor based on integrated Gaussian curvature to predict surgical success in aortic dissections by analyzing shape changes.

Acute SARS-CoV-2 infection in pregnancy is associated with placental ACE-2 shedding

This study examines ACE-2 expression and shedding in placental tissues and maternal serum during SARS-CoV-2 infection in pregnancy, finding increased soluble ACE-2 in third-trimester infections.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

The Oncoprotein BCL6 Enables Cancer Cells to Evade Genotoxic Stress

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

Variable Induction of Pro-inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

This study shows that commercial SARS CoV-2 spike protein reagents vary in their ability to induce pro-inflammatory cytokines, likely due to contamination with endotoxin (LPS).

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans

The paper investigates the origin and timing of Denisovan introgression into Tibetans at the EPAS1 locus, finding an East Asian-specific introgression event around 43,000 years ago followed by selection 12,000 years ago.

Effectively control of a viral disease with a high transmission rate through selective predation

The paper develops a shrimp aquaculture ecosystem using predatory fish to control WSSV transmission, effectively preventing outbreaks.

SVclone: inferring structural variant cancer cell fraction

SVclone infers cancer cell fractions of structural variant breakpoints from whole-genome sequencing data and identifies subclonal copy-number neutral rearrangements linked to decreased survival in certain cancers.

Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography

This study uses gold nanobipyramids as OCT contrast agents to visualize multiplexed lymphatic flows in live mice, showing distinct drainage patterns from a melanoma tumor to sentinel lymph nodes.

The evolutionary history of 2,658 cancers

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes

BaalChIP corrects allele-specific ChIP-seq analysis for copy number variation in cancer genomes, improving detection of regulatory variants.

Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions

This study introduces iMAAPs, a method to infer multiple-wave population admixture by modeling ALD decay with polynomial functions, showing improved performance over existing methods.