K. Hughes

An ovine model for investigation of the microenvironment of the male mammary gland

This study evaluates the male ovine mammary gland microenvironment, comparing intact and neutered males, and demonstrates its utility as a model for male breast biology.

In the murine and bovine maternal mammary gland signal transducer and activator of transcription 3 is activated in clusters of epithelial cells around the day of birth

The paper examines pSTAT3 expression in murine and bovine mammary glands around birth, finding non-random clustering of pSTAT3-positive cells in alveoli.

RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid

This study identifies RNA structures and N domains responsible for specific interactions and phase separation in SARS-CoV-2 nucleocapsid, showing that multiple weak interactions drive phase separation while strong interactions are specific.

Modifications to the SR-Rich Region of the SARS-CoV-2 Nucleocapsid Regulate Self-Association and Attenuate RNA Interactions

This study identifies how modifications to the SARS-CoV-2 N nucleocapsid protein's SR-rich linker region affect self-association and RNA interactions through structural and biochemical analyses.

AI-powered pan-species computational pathology: bridging clinic and wildlife care

This study develops a pan-species computational pathology atlas using AI to analyze cancer morphology across species, finding that accuracy varies with morphological similarity and introduces a new metric for veterinary applications.

Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages

This study shows HIV-1 infected macrophages transfer virus to renal epithelial cells, leading to proliferation and potential persistence of infection in the kidney.

Zygote morphogenesis but not the establishment of cell polarity in Plasmodium berghei is controlled by the small GTPase, RAB11A

This study shows that RAB11A is essential for zygote morphogenesis into ookinetes in Plasmodium berghei but not for establishing cell polarity.

Mammary mechanobiology: mechanically-activated ion channels in lactation and involution

This study investigates mechanical forces in mammary glands during lactation and involution, highlighting the role of PIEZO1 in force sensing and its physiological importance.

An examination of the evolve-and-resequence method using Drosophila simulans

The paper examines the evolve-and-resequence method in Drosophila simulans, finding that parallel evolution involves fewer polymorphisms than previously thought, with implications for selection and allele frequency dynamics.