Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
D. J. Wible, Z. Parikh, E. J. Cho, M.-D. Chen, S. Mukhopadhyay, K. N. Dalby, S. Varadarajan, S. B. Bratton
This study shows that p38 MAPK inhibitors induce cytoplasmic vacuolation by inhibiting both PIKfyve and p38 MAPKs, revealing an epistatic relationship in endolysosomal fission and volume control.
bioRxiv · Mar 13, 2023Cell Biology