S. Mukhopadhyay

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

The paper identifies a programmed cilia deconstruction pathway in cerebellar granule cells during neurogenesis, showing decreased cilia maintenance and centriole capping prevent cilia regrowth and dysregulated signaling.

The paper investigates ciliary dynamics in differentiating granule cell neurons, finding that cilia are deconstructed intracellularly and do not reform in adult neurons.

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

The paper identifies differentially expressed miRNAs between young-onset and late-onset colorectal carcinoma patients and links them to epithelial-mesenchymal transition and tumor progression.

This paper introduces disulfide bonds in the A2 and A4 loop of AfCel7A, enhancing its thermostability and catalytic activity compared to the wild type.

The paper uses single-molecule techniques to study phase separation of a prion-like domain, revealing structural subpopulations and molecular events involved in condensate formation and disease-related aggregation.

This study shows that p38 MAPK inhibitors induce cytoplasmic vacuolation by inhibiting both PIKfyve and p38 MAPKs, revealing an epistatic relationship in endolysosomal fission and volume control.

This study identifies MSR1 as a key receptor for nonopsonic phagocytosis of Cryptococcus neoformans and shows TLR4/MSR1 crosstalk in this process.

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

This study shows ATP modulates yeast prion amyloid formation and limits autocatalytic amplification by altering aggregate structure and fragmentation.

This study identifies RPB1 as a critical gene for Arabidopsis resistance to clubroot disease through natural variation screening and functional analysis.

This study shows that tau and prion proteins form dynamic condensates through electrostatic interactions, which can transition into solid-like co-aggregates with age.

The paper shows NAPs like HU-A, HU-B, and Dps form multiphasic condensates with DNA, resembling bacterial nucleoids through phase separation.

This study identifies fascin1 as a mechanosensor in colon cancer cells that modulates adherens junction plasticity, promoting tumor growth and metastasis.

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

This study uses single-droplet SERS to analyze molecular interactions in FUS condensates, revealing conformational heterogeneity and RNA effects.

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

This study investigates how prion protein and α-synuclein form dynamic condensates that influence phase transitions and amyloid conversion through electrostatic interactions and RNA effects.

This paper shows that mutations at the inter-dimer interface of alphavirus E2/E1 proteins lead to host-specific defects in viral particle assembly and morphology.

This study uses fractal analysis of TIRF microscopy images to identify two-step aggregation kinetics of Amyloid-β proteins, showing a transition from linear growth to branching.

This study shows that mutations in the NTD of alphavirus CP affect core assembly, but E2-CP interactions can rescue core formation in virions.

This study identifies how TULP3 interacts with ARL13B to transport lipidated and transmembrane proteins to cilia through specific binding motifs.

This study shows that low levels of Hsp104 promote the formation and persistence of amyloid seeds in yeast prion proteins.

This study shows that the Y145Stop variant of the prion protein undergoes liquid-liquid phase separation and transitions into amyloid-like aggregates, highlighting a potential role for intrinsically disordered regions in neurodegenerative diseases.

The paper introduces a method to identify, map, and quantify SARS-CoV-2 Spike glycopeptides using mass-retention time fingerprinting with LC-TOF mass spectrometry.

This study compares colitis severity in C57BL/6 and BALB/c mice using a DSS-induced model, finding that C57BL/6 mice exhibit more severe disease.

The paper characterizes a new AA16 family LPMO from Aspergillus fumigatus, showing it enhances biomass hydrolysis by 2-fold when combined with cellulase cocktails.

This study investigates sex differences in TMPRSS2 and ACE2 expression in human and mouse lungs and evaluates the effect of anti-androgens on these genes, finding no significant increase in TMPRSS2 but sex dimorphism in ACE2.

The paper develops interpretable deep learning models to search for similar disease states across social media and PubMed using histopathology images and clinical data, achieving high precision in real-time diagnosis assistance.