Author

S. Varadarajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1 Organism:Xenopus· 1

Frequent Co-Authors

A. B. Goryachev· 1 shared A. L. Miller· 1 shared D. J. Wible· 1 shared E. J. Cho· 1 shared E. R. Misterovich· 1 shared I. S. Erofeev· 1 shared J. L. Wu· 1 shared K. N. Dalby· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. B. Goryachev

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2 papers

Recent·Most cited

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

D. J. Wible, Z. Parikh, E. J. Cho, M.-D. Chen, S. Mukhopadhyay, K. N. Dalby, S. Varadarajan, S. B. Bratton

This study shows that p38 MAPK inhibitors induce cytoplasmic vacuolation by inhibiting both PIKfyve and p38 MAPKs, revealing an epistatic relationship in endolysosomal fission and volume control.

bioRxiv · Mar 13, 2023Cell Biology

Mechanosensitive calcium signaling promotes epithelial tight junction remodeling by activating RhoA

S. Varadarajan, R. E. Stephenson, E. R. Misterovich, J. L. Wu, I. S. Erofeev, A. B. Goryachev, A. L. Miller

The paper shows that mechanosensitive calcium flashes trigger RhoA activation, leading to tight junction remodeling in response to mechanical stress in Xenopus laevis epithelial cells.

bioRxiv · May 18, 2021Cell Biology