Author

E. J. Ostrin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. E. Spira· 1 shared A. Sinjab· 1 shared B. Sanchez-Espiridion· 1 shared B. Sepesi· 1 shared C. Behrens· 1 shared C. S. Stevenson· 1 shared D. Duose· 1 shared D. G. Rosen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. E. Spira

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy

y. chen, M. J. Hong, H. Xu, J. Vykoukal, S. Park, y. Cai, R. A. Leon-Letelier, E. Irajizad, F. C. Hsiao, J. B. Dennison, E. J. Ostrin, J. F. Fahrmann, H. Katayama, S. M. Hanash

The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

A. Sinjab, G. Han, W. Treekitkarnmongkol, K. Kobayashi, P. Brennan, M. Dang, D. Hao, R. Wang, E. Dai, H. Dejima, J. Zhang, E. Bogatenkova, B. Sanchez-Espiridion, K. Chang, D. R. Little, , H. Kadara

This study uses multi-region single-cell sequencing to map the spatial and cellular architecture of early-stage lung adenocarcinoma, revealing geospatial lineage evolution and potential therapeutic targets.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology