Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination
W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy
This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.
bioRxiv · Oct 31, 2021 · PreprintImmunology