Author

A. H. Ellebedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. J. Schmitz· 4 shared J. S. Turner· 4 shared J. A. O'Halloran· 3 shared M. S. Diamond· 3 shared R. M. Presti· 3 shared S. P. J. Whelan· 3 shared T. Lei· 3 shared Z. Liu· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersImmunology

A. J. Schmitz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

W. B. Alsoussi, S. K. Malladi, J. Q. Zhou, Z. Liu, B. Ying, W. Kim, A. J. Schmitz, T. Lei, S. C. Horvath, A. J. Sturtz, K. M. McIntire, B. Evavold, F. Han, S. M. Scheaffer, I. F. Fox, , A. H. Ellebedy

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

Nature · Apr 3, 2023Peer-reviewedImmunology

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy

This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.

bioRxiv · Oct 31, 2021 · PreprintImmunology

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants

A. J. Schmitz, J. S. Turner, Z. Liu, I. D. Aziati, R. E. Chen, A. Joshi, T. L. Bricker, T. L. Darling, D. C. Adelsberg, W. B. Al Soussi, J. B. Case, T. Lei, M. Thapa, F. Amanat, J. A. O'Halloran, , A. H. Ellebedy

A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.

bioRxiv · Mar 24, 2021Immunology

Human B cell lineages engaged by germinal centers following influenza vaccination are measurably evolving

K. B. Hoehn, J. S. Turner, F. I. Miller, R. Jiang, O. G. Pybus, A. H. Ellebedy, S. H. Kleinstein

The paper shows that influenza vaccination leads to measurable evolution in B cell lineages engaged by germinal centers, but not in blood lineages.

bioRxiv · Jan 6, 2021Immunology

Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

Z. Liu, L. A. VanBlargan, L.-M. Bloyet, P. W. Rothlauf, R. E. Chen, S. Stumpf, H. Zhao, J. M. Errico, E. S. Theel, M. J. Liebeskind, B. Alford, W. J. Buchser, A. H. Ellebedy, D. H. Fremont, M. S. Diamond, S. P. J. Whelan

bioRxiv · Nov 6, 2020 · PreprintMicrobiology

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

J. Han, A. J. Schmitz, S. T. Richey, Y. Dai, H. L. Turner, B. M. Mohammed, D. H. Fremont, A. H. Ellebedy, A. Ward

This study uses EMPEM to track human antibody responses to H5N1 vaccination, showing persistent stem-binding antibodies and transient head-binding antibodies after immunization.

bioRxiv · Jun 16, 2020Immunology