Author

W. D. Middleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. J. Schmitz· 4 shared J. S. Turner· 4 shared M. K. Klebert· 4 shared R. M. Presti· 4 shared W. Kim· 4 shared A. Haile· 3 shared J. Q. Zhou· 3 shared S. A. Teefey· 3 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

A. J. Schmitz

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Author profile →

4 papers

Recent·Most cited

Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

S. Schattgen, J. S. Turner, M. A. Ghonim, J. C. Crawford, A. J. Schmitz, H. Kim, J. Q. Zhou, W. Awad, W. Kim, K. M. McIntire, A. Haile, M. K. Klebert, T. Suessen, W. D. Middleton, S. A. Teefey, , P. Thomas

This study tracks the spatiotemporal dynamics of human T follicular helper (TFH) cells after influenza vaccination, showing clonal expansion, phenotypic changes, and lineage-specific responses over two years.

bioRxiv · Aug 29, 2023 · PreprintImmunology

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

W. B. Alsoussi, S. K. Malladi, J. Q. Zhou, Z. Liu, B. Ying, W. Kim, A. J. Schmitz, T. Lei, S. C. Horvath, A. J. Sturtz, K. M. McIntire, B. Evavold, F. Han, S. M. Scheaffer, I. F. Fox, , A. H. Ellebedy

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

Nature · Apr 3, 2023Peer-reviewedImmunology

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy

This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.

bioRxiv · Oct 31, 2021 · PreprintImmunology

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

P. A. Mudd, A. A. Minervina, M. V. Pogorelyy, J. S. Turner, W. Kim, E. Kalaidina, J. Petersen, A. J. Schmitz, T. Lei, A. Haile, A. M. Kirk, R. C. Mettelman, J. C. Crawford, T. H. O. Nguyen, L. C. Rowntree, , A. Ellebedy

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

bioRxiv · Sep 8, 2021Immunology