Author

J. Q. Zhou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. J. Schmitz· 3 shared J. S. Turner· 3 shared M. K. Klebert· 3 shared R. M. Presti· 3 shared W. D. Middleton· 3 shared W. Kim· 3 shared A. H. Ellebedy· 2 shared A. Haile· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. J. Schmitz

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Author profile →

5 papers

Recent·Most cited

Spatiotemporal development of the human T follicular helper cell response to Influenza vaccination

S. Schattgen, J. S. Turner, M. A. Ghonim, J. C. Crawford, A. J. Schmitz, H. Kim, J. Q. Zhou, W. Awad, W. Kim, K. M. McIntire, A. Haile, M. K. Klebert, T. Suessen, W. D. Middleton, S. A. Teefey, , P. Thomas

This study tracks the spatiotemporal dynamics of human T follicular helper (TFH) cells after influenza vaccination, showing clonal expansion, phenotypic changes, and lineage-specific responses over two years.

bioRxiv · Aug 29, 2023 · PreprintImmunology

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

W. B. Alsoussi, S. K. Malladi, J. Q. Zhou, Z. Liu, B. Ying, W. Kim, A. J. Schmitz, T. Lei, S. C. Horvath, A. J. Sturtz, K. M. McIntire, B. Evavold, F. Han, S. M. Scheaffer, I. F. Fox, , A. H. Ellebedy

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

Nature · Apr 3, 2023Peer-reviewedImmunology

Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

W. Kim, J. Q. Zhou, A. J. Sturtz, S. C. Horvath, A. J. Schmitz, T. Lei, E. Kalaidina, M. Thapa, W. B. Al Soussi, A. Haile, M. K. Klebert, T. Suessen, L. Parra-Rodriguez, P. A. Mudd, W. D. Middleton, , A. H. Ellebedy

This study tracks the maturation of B cell responses to SARS-CoV-2 vaccination, showing that memory B cells and bone marrow plasma cells accumulate somatic hypermutations over time, enhancing antibody avidity.

bioRxiv · Oct 31, 2021 · PreprintImmunology

Immunoglobulin heavy chains are sufficient to determine most B cell clonal relationships

J. Q. Zhou, S. H. Kleinstein

The paper assesses the sufficiency of B cell receptor heavy chains for determining clonal relationships and finds they are sufficient with high confidence.

bioRxiv · Jun 18, 2019Immunology

Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

K. B. Hoehn, J. A. Vander Heiden, J. Q. Zhou, G. Lunter, O. G. Pybus, S. H. Kleinstein

This study introduces a hierarchical phylogenetic framework to analyze B cell repertoires, revealing age-related changes in SHM motifs and a link between tree length and negative selection.

bioRxiv · Feb 25, 2019Immunology