The contribution of the ankyrin repeat domain of TRPV1 as a thermal module
L. D. Islas, E. Ladron-de-Guevara, G. E. Rangel-Yescas, A. Fernandez-Velasco, A. Torres-Larios, T. Rosenbaum
This paper investigates the role of the ankyrin repeat domain (ARD) in TRPV1 thermal sensitivity using computational and biochemical methods, finding that the ARD undergoes structural changes with temperature that may regulate channel activation.
bioRxiv · May 19, 2019Biophysics