Author

T. Rosenbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. D. Islas· 5 shared E. Ladron-de-Guevara· 2 shared E. Suarez-Delgado· 2 shared G. E. Rangel-Yescas· 2 shared A. Albert· 1 shared A. Fernandez-Velasco· 1 shared A. Sanchez-Moreno· 1 shared A. T. Banaszak· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersBiophysics

L. D. Islas

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Crucial role for Sodium Hydrogen Exchangers in SGLT2 inhibitor-induced arterial relaxations

E. A. Forrester, B.-A. Benitez-Angeles, K. E. Redford, T. Rosenbaum, G. W. Abbott, V. Barrese, K. A. Dora, A. Albert, D. Dannesboe, I. Salles-Crawley, T. A. Jepps, I. A. Greenwood

This study shows SGLT2 inhibitors relax mesenteric arteries via CGRP release from sensory nerves, mediated by NHE1 inhibition, but not renal arteries.

bioRxiv · Dec 5, 2023 · PreprintPhysiology

Cation permeability and pore dynamics in TRPV1 ion channels

M. Garcia-Avila, J. Tello Marmolejo, T. Rosenbaum, L. D. Islas

This study investigates how ion permeation affects voltage dependence in TRPV1 channels using single-channel recordings.

bioRxiv · May 25, 2023 · PreprintBiophysics

Discovery and characterization of Hv1-type proton channels in reef-building corals.

G. Rangel-Tescas, C. Cervantes, M. A. Cervantes-Rocha, E. Suarez-Delgado, A. T. Banaszak, E. Maldonado, I. S. Ramsey, T. Rosenbaum, L. D. Islas

This study identifies and characterizes Hv1-type proton channels in reef-building corals, revealing their biophysical properties and developing an allosteric gating model.

bioRxiv · Apr 8, 2021Biophysics

KV1.2 channels inactivate through a mechanism similar to C-type inactivation

E. Suarez-Delgado, T. G. Rangel-Sandin, I. G. Ishida, G. E. Rangel-Yescas, T. Rosenbaum, L. D. Islas

This study investigates slow inactivation in rat KV1.2 channels and finds similarities to C-type inactivation in Shaker channels, with some functional differences due to structural variations.

bioRxiv · Sep 26, 2019Biophysics

The contribution of the ankyrin repeat domain of TRPV1 as a thermal module

L. D. Islas, E. Ladron-de-Guevara, G. E. Rangel-Yescas, A. Fernandez-Velasco, A. Torres-Larios, T. Rosenbaum

This paper investigates the role of the ankyrin repeat domain (ARD) in TRPV1 thermal sensitivity using computational and biochemical methods, finding that the ARD undergoes structural changes with temperature that may regulate channel activation.

bioRxiv · May 19, 2019Biophysics

Irreversible temperature gating in trpv1 sheds light on channel activation

A. Sanchez-Moreno, E. Guevara-Hernandez, R. Contreras-Cervera, G. Rangel-Yescas, E. Ladron-de-Guevara, T. Rosenbaum, L. D. Islas

The paper identifies an irreversible inactivation process in TRPV1 channels triggered by thermal stimuli, linked to conformational changes in the membrane proximal domain.

bioRxiv · Jan 20, 2018Biophysics