Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes
S. Skovsø, P. Overby, J. Memar-Zadeh, J. Lee, J. C. C. Yang, I. Shanina, V. Sidarala, E. Levi-D Ancona, J. Zhu, S. A. Soleimanpour, M. Horwitz, J. D. Johnson
This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.
bioRxiv · Feb 3, 2022Immunology