Author

V. Sidarala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Zhu· 5 shared S. A. Soleimanpour· 5 shared E. C. Reck· 3 shared E. M. Walker· 3 shared G. L. Pearson· 3 shared B. A. Kaufman· 2 shared B. Thompson· 2 shared D. L. Hubers· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

J. Zhu

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Author profile →

5 papers

Recent·Most cited

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

J. Li, J. Zhu, Y. Deng, E. C. Reck, E. M. Walker, V. Sidarala, D. L. Hubers, M. B. Pasmooij, C.-S. Shin, K. Bandesh, E. Motakis, S. Nargund, R. Kursawe, V. Basrur, A. Nesvizhskii, , S. A. Soleimanpour

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

bioRxiv · Jun 3, 2024Cell Biology

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

G. L. Pearson, E. M. Walker, N. Lawlor, A. Lietzke, V. Sidarala, J. Zhu, T. Stromer, E. C. Reck, A. M. Stendahl, J. Li, E. Levi-D'Ancona, M. B. Pasmooij, D. L. Hubers, A. Renberg, K. Mohamed, , S. A. Soleimanpour

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

bioRxiv · Aug 2, 2022 · PreprintCell Biology

Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes

S. Skovsø, P. Overby, J. Memar-Zadeh, J. Lee, J. C. C. Yang, I. Shanina, V. Sidarala, E. Levi-D Ancona, J. Zhu, S. A. Soleimanpour, M. Horwitz, J. D. Johnson

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

bioRxiv · Feb 3, 2022Immunology

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

V. Sidarala, J. Zhu, E. Levi-D'Ancona, G. L. Pearson, E. C. Reck, E. M. Walker, B. A. Kaufman, S. A. Soleimanpour

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.

bioRxiv · Jan 10, 2021 · PreprintCell Biology

Mitophagy protects beta cells from inflammatory damage in diabetes

V. Sidarala, G. L. Pearson, V. S. Parekh, B. Thompson, L. Christen, M. A. Gingerich, J. Zhu, T. Stromer, J. Ren, E. Reck, B. Chai, J. A. Corbett, T. Mandrup-Poulsen, L. S. Satin, S. A. Soleimanpour

This study shows mitophagy protects beta cells from inflammatory damage in diabetes by reducing mitochondrial dysfunction and cell death.

bioRxiv · Jun 7, 2020Cell Biology