Author

P. Overby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. D. Johnson· 5 shared E. Panzhinskiy· 3 shared H. H. Cen· 3 shared J. Kolic· 3 shared J. D. Botezelli· 2 shared P. E. Macdonald· 2 shared S. Skovso· 2 shared X.-Q. Dai· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersPhysiology

J. D. Johnson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

P. Overby, A. G. Gordon, X.-Q. Dai, N. S. Nahirney, S. Provenzano, W. G. Sun, Y. Xia, J. A. Zhang, E. Panzhinskiy, C. M. J. Chu, H. H. Cen, S. Skovso, J. Kolic, A. G. Edwards, P. E. Macdonald, J. D. Johnson

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes

S. Skovsø, P. Overby, J. Memar-Zadeh, J. Lee, J. C. C. Yang, I. Shanina, V. Sidarala, E. Levi-D Ancona, J. Zhu, S. A. Soleimanpour, M. Horwitz, J. D. Johnson

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

bioRxiv · Feb 3, 2022Immunology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets

J. Kolic, L. Beet, P. Overby, H. H. Cen, E. Panzhinskiy, D. R. Ure, J. L. Cross, R. B. Huizinga, J. D. Johnson

This study compares the effects of voclosporin and tacrolimus on insulin secretion from human islets, finding that tacrolimus impairs insulin secretion while voclosporin does not.

bioRxiv · Apr 30, 2020Cell Biology

Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice

J. D. Botezelli, P. Overby, L. Lindo, S. D. Wang, O. Haida, G. E. Lim, N. M. Templeman, J. R. Pauli, J. D. Johnson

This study shows that reducing insulin in mice increases oxidative mitochondrial proteins in inguinal white adipose tissue and upregulates Ucp1 in mesenteric WAT and BAT under high-fat diet conditions.

bioRxiv · Mar 31, 2020Physiology