Author

I. Shanina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

M. S. Horwitz· 4 shared I. C. Mouat· 3 shared G. Vorobeychik· 2 shared J. R. Allanach· 2 shared V. Fan· 2 shared Z. J. Morse· 2 shared A. M. Girard· 1 shared A. R. Rosen· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersImmunology

M. S. Horwitz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Epstein-Barr virus promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

J. R. Allanach, N. M. Fettig, B. K. Hardman, V. Fan, A. R. Rosen, E. J. Goldberg, Z. J. Morse, I. Shanina, G. Vorobeychik, L. C. Osborne, M. S. Horwitz

This study shows EBV infection worsens MS in a humanized mouse model by altering T cell balance.

bioRxiv · Feb 23, 2022 · PreprintImmunology

Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes

S. Skovsø, P. Overby, J. Memar-Zadeh, J. Lee, J. C. C. Yang, I. Shanina, V. Sidarala, E. Levi-D Ancona, J. Zhu, S. A. Soleimanpour, M. Horwitz, J. D. Johnson

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

bioRxiv · Feb 3, 2022Immunology

Age-associated B cells are long-lasting effectors that restrain reactivation of latent γHV68

I. C. Mouat, I. Shanina, M. S. Horwitz

This study shows that age-associated B cells persist during latent γHV68 infection and restrain viral reactivation by producing IFNγ and TNF.

bioRxiv · Dec 29, 2021 · PreprintImmunology

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAE

I. C. Mouat, J. R. Allanach, V. Fan, A. M. Girard, I. Shanina, G. Vorobeychik, M. S. Horwitz

This study shows that gammaherpesvirus infection expands age-associated B cells (ABCs) and primes them for pathogenic roles in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).

bioRxiv · Jul 22, 2021 · PreprintImmunology

Latent gammaherpesvirus exacerbates arthritis and requires age-associated B cells

I. C. Mouat, Z. J. Morse, I. Shanina, K. L. Brown, M. S. Horwitz

This study shows that latent gammaherpesvirus infection worsens arthritis in mice by requiring age-associated B cells.

bioRxiv · Feb 2, 2021Immunology