Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action
E. M. Crisafulli, A. E. De Paoli, M. V. Tutor, G. Siddiqui, D. J. Creek, L. Tilley, S. A. Ralph
This study shows that apicoplast-targeting antibiotics reduce free haem availability, antagonizing dihydroartemisinin action in Plasmodium falciparum.
bioRxiv · Oct 31, 2021 · PreprintMicrobiology