Author

S. A. Ralph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:plant (other)· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

D. J. Creek· 2 shared G. Siddiqui· 2 shared L. Tilley· 2 shared M. S. Bulloch· 2 shared M. V. Tutor· 2 shared A. E. De Paoli· 1 shared A. Ju· 1 shared A. Lal· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

D. J. Creek

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum

M. S. Bulloch, L. K. Huynh, K. Kennedy, J. E. Ralton, M. J. McConville, S. A. Ralph

This study shows that apicoplast-derived isoprenoids are essential for GPI anchor biosynthesis in Plasmodium falciparum, which is critical for parasite egress and invasion.

bioRxiv · Feb 14, 2024 · PreprintCell Biology

The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

M. V. Tutor, G. J. Shami, G. Siddiqui, D. J. Creek, L. Tilley, S. A. Ralph

This study shows that the Plasmodium falciparum Kelch 13 protein is essential for normal cytostome formation, which is critical for haemoglobin uptake and artemisinin activation.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action

E. M. Crisafulli, A. E. De Paoli, M. V. Tutor, G. Siddiqui, D. J. Creek, L. Tilley, S. A. Ralph

This study shows that apicoplast-targeting antibiotics reduce free haem availability, antagonizing dihydroartemisinin action in Plasmodium falciparum.

bioRxiv · Oct 31, 2021 · PreprintMicrobiology

A divergent nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential

E. McHugh, M. S. Bulloch, S. Batinovic, D. K. Sarna, S. A. Ralph

This study investigates NMD in P. falciparum, finding it requires UPF2 but not UPF1, is inefficient, and not essential for parasite growth.

bioRxiv · Apr 14, 2021Microbiology

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

M. J. Boucher, S. Ghosh, L. Zhang, A. Lal, S. W. Jang, A. Ju, S. Zhang, X. Wang, S. A. Ralph, J. Zou, J. E. Elias, E. Yeh

The paper combines proteomics and machine learning to generate a high-confidence apicoplast proteome in malaria parasites, identifying 346 proteins and validating novel functions.

bioRxiv · Jul 28, 2018Microbiology