D. J. Creek

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

This study shows that the Plasmodium falciparum Kelch 13 protein is essential for normal cytostome formation, which is critical for haemoglobin uptake and artemisinin activation.

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

This study validates PfA-M17 as a novel drug target by showing its essential role in Plasmodium falciparum survival and demonstrating the efficacy of a specific inhibitor.

Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action

This study shows that apicoplast-targeting antibiotics reduce free haem availability, antagonizing dihydroartemisinin action in Plasmodium falciparum.

Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

The paper investigates kinetic competition between alternative poly(A) sites in yeast using genetic and pharmacological approaches, showing that nucleotide levels and RNAP II dynamics influence polyadenylation site selection.

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

This paper shows ozonide antimalarials disrupt Plasmodium falciparum haemoglobin digestion, leading to parasite death and stress responses.

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

The paper identifies mutations in Plasmodium falciparum pantothenate kinase genes that confer resistance to pantothenate analogues and reveal different mechanisms of action for these compounds.