Author

G. Siddiqui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:plant (other)· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1

Frequent Co-Authors

D. J. Creek· 6 shared C. Giannangelo· 3 shared A. E. De Paoli· 2 shared C. A. MacRaild· 2 shared L. Tilley· 2 shared M. V. Tutor· 2 shared N. A. Counihan· 2 shared S. A. Charman· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersMicrobiology

D. J. Creek

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

R. C. Edgar, G. Siddiqui, T. R. Malcolm, S. Duffy, M. Chowdhury, J. Marfurt, G. Wirjanata, R. Noviyanti, K. Daware, M. Dans, C. D. Suraweera, N. A. Counihan, R. N. Price, S. Whittlin, V. M. Avery, , S. McGowan

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

bioRxiv · Oct 1, 2023Microbiology

The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

M. V. Tutor, G. J. Shami, G. Siddiqui, D. J. Creek, L. Tilley, S. A. Ralph

This study shows that the Plasmodium falciparum Kelch 13 protein is essential for normal cytostome formation, which is critical for haemoglobin uptake and artemisinin activation.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

Immunopharmacological evaluation of adjuvant efficacy of Monophosphoryl lipid-A and CpG ODN with SARS-CoV-2 RBD antigen

S. Sambyal, V. Sravanthi, R. Khatri, G. Siddiqui, S. Ahmed, S. Samal, H. M. Sampath Kumar

The paper evaluates the immunopharmacological efficacy of MPL-A and CpG ODN adjuvants with SARS-CoV-2 RBD antigen, showing they elicit potent antibody responses and enhance T and B cell populations.

bioRxiv · Apr 4, 2022 · PreprintImmunology

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

R. C. S. Edgar, G. Siddiqui, K. Hjerrild, T. R. Malcolm, N. B. Vinh, C. T. Webb, C. A. MacRaild, N. A. Counihan, D. J. Creek, P. J. Scammels, S. McGowan, T. F. De Koning-Ward

This study validates PfA-M17 as a novel drug target by showing its essential role in Plasmodium falciparum survival and demonstrating the efficacy of a specific inhibitor.

bioRxiv · Nov 23, 2021Microbiology

Antibiotic inhibition of the Plasmodium apicoplast decreases haemoglobin degradation and antagonises dihydroartemisinin action

E. M. Crisafulli, A. E. De Paoli, M. V. Tutor, G. Siddiqui, D. J. Creek, L. Tilley, S. A. Ralph

This study shows that apicoplast-targeting antibiotics reduce free haem availability, antagonizing dihydroartemisinin action in Plasmodium falciparum.

bioRxiv · Oct 31, 2021 · PreprintMicrobiology

Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells

G. Siddiqui, C. Giannangelo, A. E. De Paoli, A. K. Schuh, K. Heimsch, D. Anderson, T. G. Brown, C. A. MacRaild, J. Wu, X. Wang, Y. Dong, J. L. Vennerstrom, K. Becker, D. J. Creek

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

bioRxiv · Sep 10, 2021Pharmacology & Toxicology

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

C. Giannangelo, G. Siddiqui, A. De Paoli, B. M. Anderson, L. E. Edgington-Mitchell, S. A. Charman, D. J. Creek

This paper shows ozonide antimalarials disrupt Plasmodium falciparum haemoglobin digestion, leading to parasite death and stress responses.

PLOS Pathogens · Jun 26, 2020Peer-reviewedMicrobiology