Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin
R. L. Anderson, D. V. Trivedi, S. S. Sarkar, M. Henze, W. Ma, H. Gong, C. S. Rogers, F. L. Wong, M. Morck, J. G. Seidman, K. M. Ruppel, T. C. Irving, R. Cooke, E. M. Green, J. A. Spudich
The paper shows that mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin, linking mutations to cardiomyopathy mechanisms.
bioRxiv · Mar 10, 2018Biochemistry