Author

J. G. Seidman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

C. E. Seidman· 2 shared H. Wakimoto· 2 shared J. M. Gorham· 2 shared A. Antolic· 1 shared B. N. Akerberg· 1 shared C. Perez-Cervantes· 1 shared C. S. Rogers· 1 shared C. Seidman· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

C. E. Seidman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

S. Fleischer, T. R. Nash, M. A. Tamargo, R. I. Lock, G. Venturini, M. Morsink, V. Li, M. J. Lamberti, P. L. Graney, M. Liberman, Y. Kim, R. Z. Zhuang, J. Whitehead, R. A. Friedman, R. SONI, , G. Vunjak-Novakovic

This study uses engineered human cardiac tissues to show how SLE autoantibodies affect myocardial injury through distinct binding patterns and functional effects on cardiac cells.

bioRxiv · Mar 7, 2024Bioengineering

Tbx5 maintains atrial identity by regulating an atrial enhancer network

M. E. Sweat, Y. Cao, X. Zhang, O. Burnicka-Turek, C. Perez-Cervantes, B. N. Akerberg, Q. Ma, H. Wakimoto, J. M. Gorham, M. K. Song, M. A. Trembley, P. Wang, F. Lu, M. Gianeselli, M. Prondzynski, , W. T. Pu

This study shows Tbx5 maintains atrial identity by regulating an atrial enhancer network through chromatin accessibility and looping.

bioRxiv · Apr 21, 2023Cell Biology

BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy

A. Antolic, H. Wakimoto, Z. Jiao, J. M. Gorham, S. R. DePalma, D. A. Conner, D. Y. Lee, J. Qi, J. G. Seidman, J. E. Bradner, J. D. Brown, S. M. Haldar, C. E. Seidman, M. A. Burke

This study shows BET bromodomain proteins drive inflammatory gene networks in cardiac fibroblasts, contributing to genetic dilated cardiomyopathy, and that JQ1, a BET inhibitor, reduces disease progression.

bioRxiv · Feb 9, 2020Cell Biology

Mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin

R. L. Anderson, D. V. Trivedi, S. S. Sarkar, M. Henze, W. Ma, H. Gong, C. S. Rogers, F. L. Wong, M. Morck, J. G. Seidman, K. M. Ruppel, T. C. Irving, R. Cooke, E. M. Green, J. A. Spudich

The paper shows that mavacamten stabilizes a folded-back sequestered super-relaxed state of β-cardiac myosin, linking mutations to cardiomyopathy mechanisms.

bioRxiv · Mar 10, 2018Biochemistry