Pharmacological CDK4/6 inhibition unravels a p53-induced secretory phenotype in senescent cells
B. Wang, S. Brandenburg, A. Hernandez-Segura, T. van Vliet, E. M. Jongbloed, S. M. Wilting, N. Ohtani, A. Jager, M. Demaria
This study shows that CDK4/6 inhibitors induce a non-inflammatory senescent state in non-malignant cells, which lacks the pro-tumorigenic SASP but retains paracrine senescence induction.
bioRxiv · Jun 5, 2020 · PreprintCell Biology