Author

E. M. Schleicher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G.-L. Moldovan· 3 shared A. Dhoonmoon· 2 shared C. M. Nicolae· 2 shared K. E. Clements· 2 shared A. M. Galvan· 1 shared C. L. Stump· 1 shared C. Nicolae· 1 shared L. M. Jackson· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

G.-L. Moldovan

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3 papers

Recent·Most cited

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitors

E. M. Schleicher, A. Dhoonmoon, K. E. Clements, L. M. Jackson, C. L. Stump, C. M. Nicolae, G.-L. Moldovan

The paper uses dual CRISPR screens to identify genes affecting resistance to ATR inhibitors in cancer cells.

bioRxiv · Apr 8, 2020Cancer Biology

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP- ribosyltransferase PARP14 in replication fork stability controlled by ATR

A. Dhoonmoon, E. M. Schleicher, C. M. Nicolae, K. E. Clements, G.-L. Moldovan

The paper identifies PARP14's role in replication fork stability through a CRISPR screen, showing its dependence on the ATR-CHK1 pathway.

bioRxiv · Apr 8, 2020Cancer Biology

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

E. M. Schleicher, A. M. Galvan, G.-L. Moldovan, C. Nicolae

This study shows PARP10 promotes cell proliferation and tumorigenesis by reducing replication stress through fork restart and DNA repair.

bioRxiv · Jun 2, 2018Cancer Biology