Author

G.-L. Moldovan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:genetic perturbation / CRISPR· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. M. Nicolae· 4 shared E. M. Schleicher· 3 shared K. E. Clements· 3 shared A. Dhoonmoon· 2 shared A. A. Kelso· 1 shared A. Ciccia· 1 shared A. Karamafrooz· 1 shared A. M. Galvan· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCancer Biology

C. M. Nicolae

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Author profile →

6 papers

Recent·Most cited

CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps

L. M. Pale, J. B. Khatib, C. M. Nicolae, G.-L. Moldovan

The paper identifies the HELQ-RAD52 axis as a regulator of cisplatin-induced ssDNA gap processing through CRISPR screens in human cells.

bioRxiv · Apr 17, 2024Cancer Biology

Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

Y.-C. Wang, A. A. Kelso, A. Karamafrooz, Y.-H. Chen, W.-K. Chen, C.-T. Cheng, Y. Qi, L. Gu, L. Malkas, H.-J. Kung, G.-L. Moldovan, A. Ciccia, J. M. Stark, D. K. Ann

bioRxiv · Jan 31, 2023 · PreprintCancer Biology

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitors

E. M. Schleicher, A. Dhoonmoon, K. E. Clements, L. M. Jackson, C. L. Stump, C. M. Nicolae, G.-L. Moldovan

The paper uses dual CRISPR screens to identify genes affecting resistance to ATR inhibitors in cancer cells.

bioRxiv · Apr 8, 2020Cancer Biology

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP- ribosyltransferase PARP14 in replication fork stability controlled by ATR

A. Dhoonmoon, E. M. Schleicher, C. M. Nicolae, K. E. Clements, G.-L. Moldovan

The paper identifies PARP14's role in replication fork stability through a CRISPR screen, showing its dependence on the ATR-CHK1 pathway.

bioRxiv · Apr 8, 2020Cancer Biology

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

E. M. Schleicher, A. M. Galvan, G.-L. Moldovan, C. Nicolae

This study shows PARP10 promotes cell proliferation and tumorigenesis by reducing replication stress through fork restart and DNA repair.

bioRxiv · Jun 2, 2018Cancer Biology

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

K. E. Clements, T. Thakar, C. M. Nicolae, X. Liang, H.-G. Wang, G.-L. Moldovan

This study identifies E2F7 as a regulator of chemoresistance in BRCA2-deficient cells, showing its role in enhancing PARP inhibitor and cisplatin resistance through RAD51 upregulation.

bioRxiv · Apr 3, 2018Cancer Biology