Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4+ and CD8+ T cell responses
M. H. Zhang, B. L. Scotland, Y. Jiao, E. M. Slaby, N. Truong, G. Stephanie, R. M. Pearson, G. L. Szeto
This study develops lipid-polymer hybrid nanoparticles to deliver antigens to APCs, showing they elicit distinct CD4+ and CD8+ T cell responses via different uptake mechanisms.
bioRxiv · Jan 23, 2022Bioengineering