R. M. Pearson

Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4+ and CD8+ T cell responses

This study develops lipid-polymer hybrid nanoparticles to deliver antigens to APCs, showing they elicit distinct CD4+ and CD8+ T cell responses via different uptake mechanisms.

Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model

This study shows that Hedgehog pathway inhibitors reduce heterotopic ossification in a trauma/burn mouse model by inhibiting osteoblast differentiation and systemic inflammation.