Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.
S. Khurshid, M. Montes, D. F. Comiskey, B. Shane, E. Matsa, C. Brown, H. K. Bid, R. Wang, P. Houghton, F. Rigo, D. Chandler
This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.
bioRxiv · Oct 2, 2020 · PreprintCancer Biology