Author

P. Houghton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Bandyopadhyay· 1 shared A. Baudin· 1 shared A. E. Lipsitt· 1 shared A. K. Challa· 1 shared A. R. Gilbert· 1 shared A. Sugalski· 1 shared B. Shane· 1 shared C. Brown· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Bandyopadhyay

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2 papers

Recent·Most cited

Defining function of wild-type and patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

J. Chen, K. Baxi, A. E. Lipsitt, N. R. Hensch, L. Wang, A. Baudin, D. G. Robledo, A. Bandyopadhyay, A. Sugalski, A. K. Challa, A. R. Gilbert, G. E. Tomlinson, P. Houghton, E. Y. Chen, D. S. Libich, M. S. Ignatius

The paper defines the role of wild-type and patient-specific TP53 mutations in ERMS using zebrafish models, showing tp53 loss increases tumor initiation and identifying mutation-specific effects on tumor development.

bioRxiv · Apr 21, 2021Cancer Biology

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.

S. Khurshid, M. Montes, D. F. Comiskey, B. Shane, E. Matsa, C. Brown, H. K. Bid, R. Wang, P. Houghton, F. Rigo, D. Chandler

This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.

bioRxiv · Oct 2, 2020 · PreprintCancer Biology