S. Khurshid

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.

This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.

SRSF2 regulation of MDM2 reveals splicing as a therapeutic vulnerability of the p53 pathway

This study shows that SRSF2 regulates MDM2 splicing, affecting p53 activity, and suggests splicing modulation as a potential therapeutic strategy for cancer.