Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen
G. Bashiri, L. V. Nigon, E. N. M. Jirgis, N. A. T. Ho, T. Stanborough, S. S. Dawes, E. N. Baker, E. M. M. Bulloch, J. M. Johnston
The paper identifies feedback inhibition of Mtb-MenD by DHNA through domain II, revealing a regulatory mechanism for menaquinone biosynthesis in Mycobacterium tuberculosis.
bioRxiv · Nov 14, 2019Biochemistry