Author

G. Bashiri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

D. Rifat· 2 shared E. M. M. Bulloch· 2 shared E. Nuermberger· 2 shared J. Lee· 2 shared J. M. Johnston· 2 shared J.-P. Lanoix· 2 shared N. A. T. Ho· 2 shared S. S. Dawes· 2 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

D. Rifat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway

T. Stanborough, N. A. T. Ho, E. M. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, J. Titterington, T. M. Allison, W. Jiao, J. M. Johnston

This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.

bioRxiv · Jul 12, 2022Biochemistry

Mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

D. Rifat, S.-Y. Li, T. R. Ioerger, K. Shah, J.-P. Lanoix, J. Lee, G. Bashiri, J. C. Sacchettini, E. Nuermberger

This study identifies mutations in fbiD(Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis through in vitro and in vivo experiments.

bioRxiv · Sep 10, 2020Microbiology

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen

G. Bashiri, L. V. Nigon, E. N. M. Jirgis, N. A. T. Ho, T. Stanborough, S. S. Dawes, E. N. Baker, E. M. M. Bulloch, J. M. Johnston

The paper identifies feedback inhibition of Mtb-MenD by DHNA through domain II, revealing a regulatory mechanism for menaquinone biosynthesis in Mycobacterium tuberculosis.

bioRxiv · Nov 14, 2019Biochemistry

Mutations in Rv2983 as a novel determinant of resistance to nitroimidazole drugs in Mycobacterium tuberculosis

D. Rifat, S.-Y. Li, T. Ioerger, J.-P. Lanoix, J. Lee, G. Bashiri, J. Sacchettini, E. Nuermberger

This paper identifies Rv2983 as a novel gene conferring resistance to nitroimidazole drugs in Mycobacterium tuberculosis and highlights the challenges in detecting such resistance.

bioRxiv · Oct 31, 2018 · PreprintMicrobiology