Author

J. M. Johnston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

E. M. M. Bulloch· 2 shared G. Bashiri· 2 shared N. A. T. Ho· 2 shared S. S. Dawes· 2 shared T. Stanborough· 2 shared E. N. Baker· 1 shared E. N. M. Jirgis· 1 shared E. W. Akazong· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

E. M. M. Bulloch

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2 papers

Recent·Most cited

Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway

T. Stanborough, N. A. T. Ho, E. M. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, J. Titterington, T. M. Allison, W. Jiao, J. M. Johnston

This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.

bioRxiv · Jul 12, 2022Biochemistry

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen

G. Bashiri, L. V. Nigon, E. N. M. Jirgis, N. A. T. Ho, T. Stanborough, S. S. Dawes, E. N. Baker, E. M. M. Bulloch, J. M. Johnston

The paper identifies feedback inhibition of Mtb-MenD by DHNA through domain II, revealing a regulatory mechanism for menaquinone biosynthesis in Mycobacterium tuberculosis.

bioRxiv · Nov 14, 2019Biochemistry