Author

S. S. Dawes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. M. M. Bulloch· 2 shared G. Bashiri· 2 shared J. M. Johnston· 2 shared N. A. T. Ho· 2 shared T. Stanborough· 2 shared A. Al-Zubaidi· 1 shared C.-Y. Cheung· 1 shared E. N. Baker· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

E. M. M. Bulloch

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway

T. Stanborough, N. A. T. Ho, E. M. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, J. Titterington, T. M. Allison, W. Jiao, J. M. Johnston

This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.

bioRxiv · Jul 12, 2022Biochemistry

RNase HI depletion strongly potentiates cell killing by rifampicin in mycobacteria

A. Al-Zubaidi, C.-Y. Cheung, G. M. Cook, G. Taiaroa, V. Mizrahi, J. S. Lott, S. S. Dawes

This paper shows that reducing RNase HI activity in mycobacteria increases sensitivity to rifampicin, suggesting RNase HI as a target for new antibiotics.

bioRxiv · Jul 14, 2021Microbiology

Allosteric Regulation of Vitamin K2 Biosynthesis in a Human Pathogen

G. Bashiri, L. V. Nigon, E. N. M. Jirgis, N. A. T. Ho, T. Stanborough, S. S. Dawes, E. N. Baker, E. M. M. Bulloch, J. M. Johnston

The paper identifies feedback inhibition of Mtb-MenD by DHNA through domain II, revealing a regulatory mechanism for menaquinone biosynthesis in Mycobacterium tuberculosis.

bioRxiv · Nov 14, 2019Biochemistry