Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence
E. McArthur, D. C. Rinker, Y. Cheng, Q. Wang, J. Wang, E. N. Gilbertson, G. Fudenberg, M. Pittman, K. Keough, F. Yue, K. S. Pollard, J. A. Capra
This study uses deep learning to infer 3D genome organization from ancient DNA, revealing how chromatin folding influenced phenotypic and sequence divergence between Neanderthals, Denisovans, and modern humans.
bioRxiv · Feb 7, 2022 · PreprintEvolutionary Biology