Author

K. Keough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. S. Pollard· 2 shared A. Kriegstein· 1 shared A. Pollen· 1 shared A. Williams· 1 shared B. Alvarado· 1 shared B. Martin· 1 shared D. C. Rinker· 1 shared D. L. Cintron· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersEvolutionary Biology

K. S. Pollard

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Author profile →

2 papers

Recent·Most cited

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

S. Whalen, F. Inoue, H. Ryu, T. Fair, E. Markenscoff-Papadimitriou, K. Keough, M. Kircher, B. Martin, B. Alvarado, O. Elor, D. L. Cintron, A. Williams, M. A. H. Samee, S. Thomas, R. Krencik, , K. S. Pollard

The paper uses machine learning to analyze human-chimpanzee variants in HARs, finding 43% affect chromatin state and 14% affect neurodevelopmental enhancer activity, with species-specific activity predicted by transcription factor footprints.

bioRxiv · Sep 28, 2022Evolutionary Biology

Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence

E. McArthur, D. C. Rinker, Y. Cheng, Q. Wang, J. Wang, E. N. Gilbertson, G. Fudenberg, M. Pittman, K. Keough, F. Yue, K. S. Pollard, J. A. Capra

This study uses deep learning to infer 3D genome organization from ancient DNA, revealing how chromatin folding influenced phenotypic and sequence divergence between Neanderthals, Denisovans, and modern humans.

bioRxiv · Feb 7, 2022 · PreprintEvolutionary Biology