F. Yue

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease

This study shows chronic AHR activation in muscle worsens ischemic damage in CKD and PAD by impairing muscle function and mitochondrial health.

Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of skeletal muscle.

This study identifies Sox11 as a marker of differentiating muscle satellite cells, showing reduced expression in quiescent and aged cells, but finds it dispensable for muscle development and regeneration.

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

Reconstructing the 3D genome organization of Neanderthals reveals that chromatin folding shaped phenotypic and sequence divergence

This study uses deep learning to infer 3D genome organization from ancient DNA, revealing how chromatin folding influenced phenotypic and sequence divergence between Neanderthals, Denisovans, and modern humans.

The homology analysis of ACE2 gene and its distinct expression in laboratory and wild animals

This study analyzes ACE2 gene conservation and expression patterns in 11 animals, finding high conservation but species-specific RNA and protein expression.

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

This study shows HP1α crosslinks chromatin to maintain nuclear and mitotic chromosome mechanics, independent of histone methylation.

Longitudinal multi-omics along gingivitis development reveal a suboptimal-health gum state with periodontitis-like microbiome

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts

This study shows advanced glycation end-products impair mitochondrial function and proliferation in tendon fibroblasts, contributing to diabetic tendinopathy.