Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma
S. Vichaikul, M. Gurrea-Rubio, M. A. Amin, P. L. Campbell, Q. Wu, M. N. Mattichak, W. D. Brodie, P. J. Palisoc, M. Ali, S. Muraoka, J. H. Ruth, E. N. Model, D. M. Rohraff, J. L. Hervoso, Y. Mao-Draayer, , P.-S. Tsou
This study shows that inhibiting BET proteins, particularly BRD4, reduces skin fibrosis in scleroderma models by affecting calcium signaling and gene expression.
bioRxiv · Aug 7, 2020Pharmacology & Toxicology