Author

A. Sawalha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P.-S. Tsou· 2 shared B. Kaur· 1 shared B. Miglioranza Scavuzzi· 1 shared D. A. Fox· 1 shared D. Khanna· 1 shared D. M. Rohraff· 1 shared E. A. Farkash· 1 shared E. N. Model· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

P.-S. Tsou

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3 papers

Recent·Most cited

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

B. Miglioranza Scavuzzi, V. van Drongelen, B. Kaur, J. Callahan Fox, J. Liu, R. A. Mesquita-Ferrari, J. M. Kahlenberg, E. A. Farkash, F. Benavides, F. W. Miller, A. Sawalha, J. Holoshitz

This study identifies a DRB1*03:01-encoded epitope that drives a lupus-like transcriptome and cellular aberrations in macrophages, revealing a noncanonical mechanism of HLA-disease association in SLE.

bioRxiv · May 31, 2022 · PreprintImmunology

Inhibition of histone readers bromodomain extra-terminal proteins alleviates skin fibrosis in experimental models of scleroderma

S. Vichaikul, M. Gurrea-Rubio, M. A. Amin, P. L. Campbell, Q. Wu, M. N. Mattichak, W. D. Brodie, P. J. Palisoc, M. Ali, S. Muraoka, J. H. Ruth, E. N. Model, D. M. Rohraff, J. L. Hervoso, Y. Mao-Draayer, , P.-S. Tsou

This study shows that inhibiting BET proteins, particularly BRD4, reduces skin fibrosis in scleroderma models by affecting calcium signaling and gene expression.

bioRxiv · Aug 7, 2020Pharmacology & Toxicology

Caffeine downregulates inflammatory pathways involved in autoimmunity

M. Iris, P.-S. Tsou, A. Sawalha

This study shows caffeine reduces inflammatory gene expression and cytokine levels in PBMCs, suggesting potential therapeutic effects in autoimmune diseases.

bioRxiv · Dec 31, 2017Immunology