S. Ito

Model-based analysis of the circadian rhythm generation of bioluminescence reporter activity in duckweed

This study uses model-based analysis to determine that luminescence efficiency, not luciferase stability, drives circadian bioluminescence rhythms in duckweed.

Florigen-producing cells express FPF1-LIKE PROTEIN 1 that accelerates flowering and stem growth in long days with sunlight red/far-red ratio in Arabidopsis

The paper identifies FLP1 as a gene expressed in FT-producing cells in Arabidopsis that promotes flowering and stem growth under long-day conditions.

Low-CO2 inducible bestrophins in diatom thylakoid membranes sustain high photosynthetic efficacy at distant locations from the pyrenoid

This study identifies PtBST1 in diatoms as a bestrophin that facilitates HCO3- transport at the stroma thylakoid membrane, enhancing CO2 concentrating mechanism and modulating photoprotection.

Injectable microcapillary network hydrogels engineered by liquid-liquid phase separation for stem cell transplantation

This paper develops injectable hydrogels with microcapillary networks to improve stem cell transplantation by enhancing tissue integration and graft survival.

UV-induced feather color change reflects its porphyrin content

This study shows that porphyrin, a minority pigment, explains UV-induced feather color change in barn swallows, challenging the focus on predominant pigments like pheomelanin.

Association of NOTCH3 with Elastic Fiber Dispersion in the Infrarenal Abdominal Aorta of Cynomolgus Monkeys

The paper examines regional heterogeneity in aortas of cynomolgus monkeys, finding increased NOTCH3 and dispersed elastic fibers in the infrarenal region.

Mechanistic insights into the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control

This study elucidates the mechanism of the UFM1 E3 ligase complex in ufmylation and its role in ER-RQC by showing its interaction with CDK5RAP3 and ufmylated RPL26.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

This study identifies 2-thiouridine as a broad-spectrum antiviral against SARS-CoV-2 and other positive-strand RNA viruses by inhibiting viral RNA synthesis.

Genetic architecture and evolution of color variation in American black bears

This study identifies a missense mutation in TYRP1 responsible for the cinnamon color morph in American black bears and traces its evolutionary origin and spread.

LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis

This study identifies LUZP1 as a novel regulator of cytokinesis by modulating the constriction velocity of the contractile ring through interactions with DAPK3 and MYL9.

No circadian clock-gene circuit in the generation of cellular bioluminescence rhythm of CaMV35S::PtRLUC in duckweed

The paper shows that the CaMV35S::PtRLUC bioluminescence rhythm in duckweed is not controlled by the circadian clock gene circuit, unlike the AtCCA1::LUC+ rhythm.

Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

Circadian-period variation underlies the local adaptation of photoperiodism in the short-day plant Lemna aequinoctialis.

This study shows that variation in the circadian free-running period (FRP) correlates with adaptive photoperiodism traits in Lemna aequinoctialis, linking chronotype variation to local adaptation.

Hotmelt tissue adhesive with supramolecularly-controlled sol-gel transition for preventing postoperative abdominal adhesion

This paper develops a hotmelt tissue adhesive that prevents postoperative abdominal adhesions by controlling sol-gel transitions through supramolecular hydrogen bonding.

Interspecific divergence of circadian properties in duckweed plants

The paper compares circadian rhythms in duckweed species across temperature and light conditions, finding differences linked to phylogeny and morphology.

Retinal vibrations in bacteriorhodopsin are mechanically harmonic but electronically anharmonic: evidence from overtone and combination bands

The paper studies retinal vibrations in bacteriorhodopsin using IR and Raman spectroscopy, finding electronic anharmonicity explains overtone band intensities better than mechanical anharmonicity.

An endogenous basis for synchronization manners of the circadian rhythm in proliferating Lemna minor plants

This study investigates circadian rhythm synchronization in Lemna minor plants using bioluminescence reporters, revealing local coupling as the mechanism for phase pattern formation in the absence of long-distance communication.

The lysosomal chloride-proton exchanger CLC7 functions in melanosomes as a negative regulator of human pigmentation

The paper shows CLC7/OSTM1 acidifies melanosomes and negatively regulates pigmentation, with OCA2 counteracting CLC7 mutations.

Experimental evaluation of thermodynamic speed limit in living cells via information geometry

The paper experimentally tests the thermodynamic speed limit in living cells using fluorescence imaging data to quantify the intrinsic speed of cell proliferation.

Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

This study determines the crystal structure of human serum albumin bound to dalbavancin, revealing the binding mechanism and structural changes involved.

On-rate modulation of cadherin interactions by chemical fragments

This study identifies a chemical fragment that modulates the on-rate of P-cadherin dimerization by inhibiting cell adhesion.

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

Detection of uncoupled circadian rhythms in individual cells of Lemna minor using a dual-color bioluminescence monitoring system

This paper develops a dual-color bioluminescence monitoring system to observe circadian rhythms in individual Lemna minor cells, revealing uncoupling between oscillator and output.

A ballistic pollen dispersal strategy hidden in stylar oscillation

The paper reveals that the pollen-bearing style in Asteraceae flowers functions as a ballistic lever to catapult pollen to pollinators, optimizing pollen transfer efficiency.