The Heterochromatin protein 1 is a master regulator in RNA splicing precision deficient in ulcerative colitis
J. Mata -Garrido, Y. Xiang, Y. Chang-Marchand, C. Reisacher, E. Ageron-ardila, C. Guerrera, I. Casafont, A. Bruneau, C. Cherbuy, X. Treton, A. Dumay, E. Ogier-Denis, E. Batsche, M. Costallat, G. Revechon, , L. Arbibe
This study identifies HP1γ as a regulator of RNA splicing in the gut, showing its deficiency leads to splicing errors and progerin production, linking it to ulcerative colitis and aging diseases.
bioRxiv · Dec 30, 2020Cell Biology