A. Papantonis

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

The paper investigates cohesin and CTCF chromatin binding dynamics during zebrafish embryogenesis, showing increased binding efficiency and its role in chromatin architecture formation.

Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy in pancreatic cancer

The paper identifies AP1 transcription factor dichotomy and CD68+ macrophages as drivers of intratumoral subtype co-existence and therapy response in pancreatic cancer.

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics

The paper investigates how transcription and loop extrusion interact to influence promoter and enhancer dynamics through live tracking and simulations.

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

Cilium induction triggers differentiation of glioma stem cells

This study shows that inducing ciliogenesis in glioma stem cells (GSCs) promotes their differentiation and prevents brain infiltration, suggesting cilium induction as a therapeutic strategy for glioblastoma.

Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence

The paper identifies an early chromosomal inversion that enables escape from oncogene-induced senescence by activating BHLHE40 and promoting malignant transformation.

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

The paper identifies a CHD6 mutation causing Hallermann-Streiff syndrome and shows it disrupts autophagy and DNA damage response through chromatin remodeling.

Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription control

This study investigates the roles of SA1 and SA2 cohesin subunits in chromatin looping and transcription control using HCT116 cells and human neural stem cells.

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

The paper shows that transcription and spatial chromosome folding increase DNA fragility, leading to oncogenic translocations in leukemia.

Shaping Epigenetic Memory via Genomic Bookmarking

This paper introduces a biophysical model of genomic bookmarking to explain how epigenetic domains are maintained and modified through histone marks and protein interactions in Drosophila.